Cyclin A2 promotes DNA repair in the brain during both development and aging
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چکیده
منابع مشابه
Cyclin A2 promotes DNA repair in the brain during both development and aging
Various stem cell niches of the brain have differential requirements for Cyclin A2. Cyclin A2 loss results in marked cerebellar dysmorphia, whereas forebrain growth is retarded during early embryonic development yet achieves normal size at birth. To understand the differential requirements of distinct brain regions for Cyclin A2, we utilized neuroanatomical, transgenic mouse, and mathematical m...
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DNA is a precious molecule. It encodes vital information about cellular content and function. There are only two copies of each chromosome in the cell, and once the sequence is lost no replacement is possible. The irreplaceable nature of the DNA sets it apart from other cellular molecules, and makes it a critical target for age-related deterioration. To prevent DNA damage cells have evolved ela...
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متن کاملSURVEY AND SUMMARY Changes in DNA repair during aging
DNA is a precious molecule. It encodes vital information about cellular content and function. There are only two copies of each chromosome in the cell, and once the sequence is lost no replacement is possible. The irreplaceable nature of the DNA sets it apart from other cellular molecules, and makes it a critical target for age-related deterioration. To prevent DNA damage cells have evolved ela...
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ژورنال
عنوان ژورنال: Aging
سال: 2016
ISSN: 1945-4589
DOI: 10.18632/aging.100990